WHAT IS JWH018 ONLINE?
JWH018 ONLINE is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55,212-2 when tested in rats.
It is a research chemical that belongs to the naphthoylindole family. JWH-081 as all the other research chemicals in the JWH group is a synthetic cannabinoid with analgesic effects.Its full chemical name is 4-methoxynaphthalen- 1-yl- (1-pentylindol- 3-yl)methanone with chemical formula as C25H25NO2 and molecular mass 371.47 g/mol.
Designer drugs, created to avoid drug laws, appear at a remarkable pace. ‘Spice’ refers to designer cannabinoids such as JWH-018, JWH-073, JWH-200 and (C8)-CP 47,497, initially found in ‘herbal smoking blends’; these are sold under many names, including K2, fake weed, Yucatan fire, skunk, moon rocks and others. Synthetic cannabinoid agonists, including RCS-4, RCS-8 and AB-001, are also available. Spice abusers report tachycardia, vomiting, agitation, confusion and hallucinations. Spice can raise blood pressure and cause myocardial ischaemia, and has occasionally been associated with heart attacks. Regular users may experience withdrawal and addiction symptoms. One concern is that there may be harmful heavy metal residues in spice mixtures.
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